| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FBXW11 |
| Gene ID: |
23291 |
| Uniprot ID: |
FBW1B_HUMAN |
| Immunogen Region: |
519-542 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 443-542 of human FBXW11 (NP_036432.2). |
| Immunogen Sequence: |
EELVRCIRFDNKRIVSGAYD GKIKVWDLQAALDPRAPAST LCLRTLVEHSGRVFRLQFDE FQIISSSHDDTILIWDFLNV PPSAQNETRSPSRTYTYISR |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation. SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription. The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68.this is required for centriole separation during mitosis. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2. SCF(FBXW11) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF. (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. |
| Protein Name | F-Box/Wd Repeat-Containing Protein 11F-Box And Wd Repeats Protein Beta-Trcp2F-Box/Wd Repeat-Containing Protein 1bHomologous To Slimb ProteinHos |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-202424Reactome: R-HSA-2565942Reactome: R-HSA-2871837Reactome: R-HSA-5607761Reactome: R-HSA-5607764Reactome: R-HSA-5676590Reactome: R-HSA-5684264Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-F-Box/Wd Repeat-Containing Protein 11 antibodyAnti-F-Box And Wd Repeats Protein Beta-Trcp2 antibodyAnti-F-Box/Wd Repeat-Containing Protein 1b antibodyAnti-Homologous To Slimb Protein antibodyAnti-Hos antibodyAnti-FBXW11 antibodyAnti-BTRCP2 antibodyAnti-FBW1B antibodyAnti-FBXW1B antibodyAnti-KIAA0696 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
