• Immunohistochemistry of mouse muscle with Anti-Fbx32 primary antibody (STJ500183) at 1:50 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-Fbx32 antibody (240-280) (STJ500183)

SKU:
STJ500183-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Fbx32 (240-280) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.64-0.72 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Arf1
Gene ID: 64310
Uniprot ID: ARF1_RAT
Immunogen Region: 240-280
Immunogen: Synthetic peptide taken within amino acid region 240-280 on Atr1 protein.
Function Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity.the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Protein Name Adp-Ribosylation Factor 1
Database Links Reactome: R-RNO-1660499
Reactome: -RNO-1660514
Reactome: -RNO-199992
Reactome: -RNO-2132295
Reactome: -RNO-432720
Reactome: -RNO-432722
Reactome: -RNO-6807878
Reactome: -RNO-6811434
Reactome: -RNO-6811438
Cellular Localisation Golgi Apparatus Membrane
Lipid-Anchor
Cytoplasmic Side
Synapse
Synaptosome
Postsynaptic Density
In The Gdp-Bound Form
Associates Transiently With The Membranes Via Its Myristoylated N-Terminus Where Guanine Nucleotide-Exchange Factor (Gef)-Mediated Nucleotide Exchange Occurs
Following Nucleotide Exchange
The Gtp-Bound Form Undergoes A Conformational Change
Leading To The Exposure Of A Myristoylated N-Terminal Amphipathic Helix That Provides Stable Membrane Anchorage
Alternative Antibody Names Anti-Adp-Ribosylation Factor 1 antibody
Anti-Arf1 antibody

Information sourced from Uniprot.org

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