Immunofluorescence analysis of mouse kidney using FBP1 Rabbit monoclonal antibody (STJ11101382) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Anti-FBP1 antibody (239-338) [S2MR] (STJ11101382)

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STJ11101382
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S2MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:1000-1:6000
IF/ICC:1:100-1:400
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FBP1
Gene ID: 2203
Uniprot ID: F16P1_HUMAN
Immunogen Region: 239-338
Specificity: A synthetic peptide corresponding to a sequence within amino acids 239-338 of human FBP1 (P09467).
Immunogen Sequence: APYGARYVGSMVADVHRTLV YGGIFLYPANKKSPNGKLRL LYECNPMAYVMEKAGGMATT GKEAVLDVIPTDIHQRAPVI LGSPDDVLEFLKVYEKHSAQ
Tissue Specificity Expressed in pancreatic islets.
Function Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity.increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Protein Name Fructose-1 -6-Bisphosphatase 1
Fbpase 1
D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1
Liver Fbpase
Database Links Reactome: R-HSA-70263
Alternative Antibody Names Anti-Fructose-1 -6-Bisphosphatase 1 antibody
Anti-Fbpase 1 antibody
Anti-D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1 antibody
Anti-Liver Fbpase antibody
Anti-FBP1 antibody
Anti-FBP antibody

Information sourced from Uniprot.org

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