Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Gene Symbol: | FASTKD2 |
Gene ID: | 22868 |
Uniprot ID: | FAKD2_HUMAN |
Immunogen Region: | 439-710 aa |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 439-710 of human FASTKD2 (NP_055744.2). |
Immunogen Sequence: | LFMKRIVEDPESLNMKNILS ILHTYSSLNHVYKCQNKEQF VEVMASALTGYLHTISSENL LDAVYSFCLMNYFPLAPFNQ LLQKDIISELLTSDDMKNAY KLHTLDTCLKLDDTVYLRDI ALSLPQLPRELPSSHTNAKV AEVLSSLLGGEGHFSKDVHL PHNYHIDFEIRMDTNRNQVL PLSDVDTTSATDIQRVAVLC VSRSAYCLGSSHPRGFLAMK MRHLNAMGFHVILVNNWEM |
Tissue Specificity | Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle and thyroid. |
Function | Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis. |
Protein Name | Fast Kinase Domain-Containing Protein 2 - Mitochondrial |
Database Links | Reactome: R-HSA-9837092 |
Cellular Localisation | Mitochondrion MatrixMitochondrion NucleoidLocalizes To Mitochondrial Rna Granules Found In Close Proximity To The Mitochondrial Nucleoids |
Alternative Antibody Names | Anti-Fast Kinase Domain-Containing Protein 2 - Mitochondrial antibodyAnti-FASTKD2 antibodyAnti-KIAA0971 antibody |
Information sourced from Uniprot.org