| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Fas-activated serine/threonine kinase (361-410 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FASTK |
| Gene ID: | 10922 |
| Uniprot ID: | FASTK_HUMAN |
| Immunogen Region: | 361-410 aa |
| Specificity: | FAST Polyclonal Antibody detects endogenous levels of FAST protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human FAST at the amino acid range 361-410 |
| Post Translational Modifications | Autophosphorylated on serine/threonine residues. Activated by dephosphorylation. |
| Function | Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. Isoform 4: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. |
| Protein Name | Fas-Activated Serine/Threonine KinaseFast Kinase |
| Database Links | Reactome: R-HSA-9837092 Q14296-4 |
| Cellular Localisation | Isoform 4: Mitochondrion MatrixColocalizes With Mitochondrial Rna Granules |
| Alternative Antibody Names | Anti-Fas-Activated Serine/Threonine Kinase antibodyAnti-Fast Kinase antibodyAnti-FASTK antibody |
Information sourced from Uniprot.org
