| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FANCA |
| Gene ID: | 2175 |
| Uniprot ID: | FANCA_HUMAN |
| Immunogen Region: | 1-275 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human FANCA (NP_000126.2). |
| Immunogen Sequence: | MSDSWVPNSASGQDPGGRRR AWAELLAGRVKREKYNPERA QKLKESAVRLLRSHQDLNAL LLEVEGPLCKKLSLSKVIDC DSSEAYANHSSSFIGSALQD QASRLGVPVGILSAGMVASS VGQICTAPAETSHPVLLTVE QRKKLSSLLEFAQYLLAHSM FSRLSFCQELWKIQSSLLLE AVWHLHVQGIVSLQELLESH PDMHAVGSWLFRNLCCLCEQ MEASCQHADVARAMLSDFV |
| Post Translational Modifications | Phosphorylation is required for the formation of the nuclear complex. Not phosphorylated in cells derived from groups A, B, C, E, F, G, and H. |
| Function | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. |
| Protein Name | Fanconi Anemia Group A ProteinProtein Faca |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-9833482 |
| Cellular Localisation | NucleusCytoplasmThe Major Form Is NuclearThe Minor Form Is Cytoplasmic |
| Alternative Antibody Names | Anti-Fanconi Anemia Group A Protein antibodyAnti-Protein Faca antibodyAnti-FANCA antibodyAnti-FAA antibodyAnti-FACA antibodyAnti-FANCH antibody |
Information sourced from Uniprot.org