| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FAM96B (1-163) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CIAO2B |
| Gene ID: |
51647 |
| Uniprot ID: |
CIA2B_HUMAN |
| Immunogen Region: |
1-163 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human FAM96B (NP_057146.1). |
| Immunogen Sequence: |
MVGGGGVGGGLLENANPLIY QRSGERPVTAGEEDEQVPDS IDAREIFDLIRSINDPEHPL TLEELNVVEQVRVQVSDPES TVAVAFTPTIPHCSMATLIG LSIKVKLLRSLPQRFKMDVH ITPGTHASEHAVNKQLADKE RVAAALENTHLLEVVNQCLS ARS |
| Function | Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. |
| Protein Name | Cytosolic Iron-Sulfur Assembly Component 2bMss19-Interacting Protein Of 18 KdaMitotic Spindle-Associated Mmxd Complex Subunit Mip18Protein Fam96b |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleMidbodyIn MitosisLocalizes To The Spindle During Metaphase And The Spindle Midbody During TelophaseCo-Localizes With Kif4a To The Spindle Midzone And Midbody During Telophase And Cytokinesis |
| Alternative Antibody Names | Anti-Cytosolic Iron-Sulfur Assembly Component 2b antibodyAnti-Mss19-Interacting Protein Of 18 Kda antibodyAnti-Mitotic Spindle-Associated Mmxd Complex Subunit Mip18 antibodyAnti-Protein Fam96b antibodyAnti-CIAO2B antibodyAnti-CIAB antibodyAnti-FAM96B antibodyAnti-MIP18 antibodyAnti-CGI-128 antibodyAnti-HSPC118 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
