| Function | Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. |
| Protein Name | Cytosolic Iron-Sulfur Assembly Component 2bMss19-Interacting Protein Of 18 KdaMitotic Spindle-Associated Mmxd Complex Subunit Mip18Protein Fam96b |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleMidbodyIn MitosisLocalizes To The Spindle During Metaphase And The Spindle Midbody During TelophaseCo-Localizes With Kif4a To The Spindle Midzone And Midbody During Telophase And Cytokinesis |
| Alternative Antibody Names | Anti-Cytosolic Iron-Sulfur Assembly Component 2b antibodyAnti-Mss19-Interacting Protein Of 18 Kda antibodyAnti-Mitotic Spindle-Associated Mmxd Complex Subunit Mip18 antibodyAnti-Protein Fam96b antibodyAnti-CIAO2B antibodyAnti-CIAB antibodyAnti-FAM96B antibodyAnti-MIP18 antibodyAnti-CGI-128 antibodyAnti-HSPC118 antibody |
Information sourced from Uniprot.org
