| Tissue Specificity | Expressed in primary fetal mononuclear myoblast. Expressed strongly in naive T lymphocytes. Expressed weakly in activated T lymphocytes (at protein level). Expressed in blood cells and adult tissues of hematopoietic origin, such as the secondary lymphoid organs. Expressed in cytotrophoblast. |
| Post Translational Modifications | Phosphorylated. Isoform 2 is phosphorylated in T cells. Chemokine-induced phosphorylation of isoform 2 in neutrophils occurs in a PKC- and AKT-dependent manner, resulting in RIPOR2 interaction with YWHAB and stabilization. Isoform 2 is phosphorylated by PKCA, AKT1 and MAPKAPK1A.in vitro. Acetylated during myogenic differentiation. |
| Function | Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing. Isoform 2: Acts as an inhibitor of the small GTPase RHOA. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state. |
| Protein Name | Rho Family-Interacting Cell Polarization Regulator 2 |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionFilopodiumStereociliumStereocilium MembraneApical Cell MembraneLocalized In The Cytoplasm In Cells Undergoing MitosisColocalized With F-ActinLocalized With Rhoc Within The Basal Domain Of Hair Cell StereociliaNear The Taper RegionDetected In Punctate Pattern Forming A Circumferential Ring At The Stereocilia BaseLocalized To The Apical Stereocilia Of Inner And Outer Hair CellsNot Detected As A Membrane-Associated Protein In StereociliaIsoform 1: CytoplasmIsoform 2: CytoplasmAccumulates At The Leading Edge Of Polarized Neutrophils In A Chemokine-Dependent Manner |
| Alternative Antibody Names | Anti-Rho Family-Interacting Cell Polarization Regulator 2 antibodyAnti-RIPOR2 antibodyAnti-C6orf32 antibodyAnti-DIFF48 antibodyAnti-FAM65B antibodyAnti-KIAA0386 antibodyAnti-PL48 antibody |
Information sourced from Uniprot.org
