| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATPSCKMT |
| Gene ID: | 134145 |
| Uniprot ID: | ACKMT_HUMAN |
| Immunogen Region: | 1-233 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FAM173B (NP_954584.2). |
| Immunogen Sequence: | MEGGGGIPLETLKEESQSRH VLPASFEVNSLQKSNWGFLL TGLVGGTLVAVYAVATPFVT PALRKVCLPFVPATTKQIEN VVKMLRCRRGSLVDIGSGDG RIVIAAAKKGFTAVGYELNP WLVWYSRYRAWREGVHGSAK FYISDLWKVTFSQYSNVVIF GVPQMMLQLEKKLERELEDD ARVIACRFPFPHWTPDHVTG EGIDTVWAYDASTFRGREKR PCTSMHFQLPIQA |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia. |
| Protein Name | Atp Synthase Subunit C Lysine N-MethyltransferaseProtein N-Lysine Methyltransferase Fam173bHfam173b |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Membrane ProteinLocalizes To Mitochondrial Cristae |
| Alternative Antibody Names | Anti-Atp Synthase Subunit C Lysine N-Methyltransferase antibodyAnti-Protein N-Lysine Methyltransferase Fam173b antibodyAnti-Hfam173b antibodyAnti-ATPSCKMT antibodyAnti-FAM173B antibody |
Information sourced from Uniprot.org