| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FADS2 (1-444) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FADS2 |
| Gene ID: |
9415 |
| Uniprot ID: |
FADS2_HUMAN |
| Immunogen Region: |
1-444 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-444 of human FADS2 (NP_004256.1). |
| Immunogen Sequence: |
MGKGGNQGEGAAEREVSVPT FSWEEIQKHNLRTDRWLVID RKVYNITKWSIQHPGGQRVI GHYAGEDATDAFRAFHPDLE FVGKFLKPLLIGELAPEEPS QDHGKNSKITEDFRALRKTA EDMNLFKTNHV |
| Tissue Specificity | Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues.lowest levels were found in patients with poor prognostic index. |
| Function | Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively. Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function. Desaturates hexadecanate (palmitate) to produce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans and major component of human sebum, that has been implicated in the development of acne and may have potent antibacterial activity. It can also desaturate (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 6 generating (6Z,11E)-octadecadienoate. In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates. |
| Protein Name | Acyl-Coa 6-DesaturaseDelta(6 Fatty Acid DesaturaseD6dDelta(6 DesaturaseDelta-6 DesaturaseFatty Acid Desaturase 2 |
| Database Links | Reactome: R-HSA-2046105Reactome: R-HSA-2046106 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Acyl-Coa 6-Desaturase antibodyAnti-Delta(6 Fatty Acid Desaturase antibodyAnti-D6d antibodyAnti-Delta(6 Desaturase antibodyAnti-Delta-6 Desaturase antibodyAnti-Fatty Acid Desaturase 2 antibodyAnti-FADS2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
