| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | F2RL3 |
| Gene ID: | 9002 |
| Uniprot ID: | PAR4_HUMAN |
| Immunogen Region: | 20-150 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human F2RL3 (NP_003941.2). |
| Immunogen Sequence: | TQTPSVYDESGSTGGGDDST PSILPAPRGYPGQVCANDSD TLELPDSSRALLLGWVPTRL VPALYGLVLVVGLPANGLAL WVLATQAPRLPSTMLLMNLA AADLLLALALPPRIAYHLRG QRWPFGEAACR |
| Tissue Specificity | Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets. |
| Post Translational Modifications | A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. |
| Function | Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. |
| Protein Name | Proteinase-Activated Receptor 4Par-4Coagulation Factor Ii Receptor-Like 3Thrombin Receptor-Like 3 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-456926 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Proteinase-Activated Receptor 4 antibodyAnti-Par-4 antibodyAnti-Coagulation Factor Ii Receptor-Like 3 antibodyAnti-Thrombin Receptor-Like 3 antibodyAnti-F2RL3 antibodyAnti-PAR4 antibody |
Information sourced from Uniprot.org
