| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EXTL3 (52-220) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EXTL3 |
| Gene ID: |
2137 |
| Uniprot ID: |
EXTL3_HUMAN |
| Immunogen Region: |
52-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 52-220 of human EXTL3 (NP_001431.1). |
| Immunogen Sequence: |
TTLDEADEAGKRIFGPRVGN ELCEVKHVLDLCRIRESVSE ELLQLEAKRQELNSEIAKLN LKIEACKKSIENAKQDLLQL KNVISQTEHSYKELMAQNQP KLSLPIRLLPEKDDAGLPPP KATRGCRLHNCFDYSRCPLT SGFPVYVYDSDQFVFGSYLD PLVKQAFQA |
| Tissue Specificity | Ubiquitous. Expressed in keratinocytes. Expressed in pancreas. |
| Function | Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker. May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity). Lacks glucuronyl transferase II (GlcAT-II) activity. Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion. Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway. Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. Required for the inhibition of skin inflammation mediated by REGA through the activation of PI3K-AKT-STAT3 pathway. Required for the function of REGA and REG3G in glucose tolerance in pancreas. Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death. |
| Protein Name | Exostosin-Like 3Ext-Related Protein 1Glucuronyl-Galactosyl-Proteoglycan 4-Alpha-N-AcetylglucosaminyltransferaseHereditary Multiple Exostoses Gene IsologMultiple Exostosis-Like Protein 3Putative Tumor Suppressor Protein Extl3 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusCell MembraneNucleusInteraction With Reg3a Induces Its Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Exostosin-Like 3 antibodyAnti-Ext-Related Protein 1 antibodyAnti-Glucuronyl-Galactosyl-Proteoglycan 4-Alpha-N-Acetylglucosaminyltransferase antibodyAnti-Hereditary Multiple Exostoses Gene Isolog antibodyAnti-Multiple Exostosis-Like Protein 3 antibodyAnti-Putative Tumor Suppressor Protein Extl3 antibodyAnti-EXTL3 antibodyAnti-EXTL1L antibodyAnti-EXTR1 antibodyAnti-KIAA0519 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
