| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EXTL3 |
| Gene ID: | 2137 |
| Uniprot ID: | EXTL3_HUMAN |
| Immunogen Region: | 52-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 52-220 of human EXTL3 (NP_001431.1). |
| Immunogen Sequence: | TTLDEADEAGKRIFGPRVGN ELCEVKHVLDLCRIRESVSE ELLQLEAKRQELNSEIAKLN LKIEACKKSIENAKQDLLQL KNVISQTEHSYKELMAQNQP KLSLPIRLLPEKDDAGLPPP KATRGCRLHNCFDYSRCPLT SGFPVYVYDSDQFVFGSYLD PLVKQAFQA |
| Tissue Specificity | Ubiquitous. Expressed in keratinocytes. Expressed in pancreas. |
| Function | Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker. May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity). Lacks glucuronyl transferase II (GlcAT-II) activity. Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion. Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway. Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. Required for the inhibition of skin inflammation mediated by REG3A through the activation of PI3K-AKT-STAT3 pathway. Required for the function of REG3A and REG3G in glucose tolerance in pancreas. Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death. |
| Protein Name | Exostosin-Like 3 Ext-Related Protein 1 Glucuronyl-Galactosyl-Proteoglycan 4-Alpha-N-Acetylglucosaminyltransferase Hereditary Multiple Exostoses Gene Isolog Multiple Exostosis-Like Protein 3 Putative Tumor Suppressor Protein Extl3 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Golgi Apparatus Cell Membrane Nucleus Interaction With Reg3a Induces Its Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Exostosin-Like 3 antibody Anti-Ext-Related Protein 1 antibody Anti-Glucuronyl-Galactosyl-Proteoglycan 4-Alpha-N-Acetylglucosaminyltransferase antibody Anti-Hereditary Multiple Exostoses Gene Isolog antibody Anti-Multiple Exostosis-Like Protein 3 antibody Anti-Putative Tumor Suppressor Protein Extl3 antibody Anti-EXTL3 antibody Anti-EXTL1L antibody Anti-EXTR1 antibody Anti-KIAA0519 antibody |
Information sourced from Uniprot.org