Anti-EXD2 antibody (STJA0004825)

SKU:
STJA0004825

Current Stock:
Host: Rabbit
Applications: WB/IHC/ELISA
Reactivity: Human/Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Exonuclease 3 5 Domain-Containing Protein 2 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification: Antigen affinity purification
Concentration: 0.96 mg/mL
Dilution Range: WB 1:500-1:2000, IHC 1:40-1:200
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: EXD2
Gene ID: 55218
Uniprot ID: EXD2_HUMAN
Immunogen: Fusion protein of human EXD2
Function Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation.
Protein Name Exonuclease 3'-5' Domain-Containing Protein 2
3'-5' Exoribonuclease Exd2
Exonuclease 3'-5' Domain-Like-Containing Protein 2
Cellular Localisation Mitochondrion Outer Membrane
Single-Pass Membrane Protein
Mitochondrion Matrix
Nucleus
Chromosome
Mainly Localizes To The Mitochondrial Outer Membrane
May Translocate To The Nucleus In Response To Dna Damage
However Mechanism That Explain Nuclear Localization Are Unknown And Require Experimental Evidences
Recruited To Replication Forks Following Replication Stress
Alternative Antibody Names Anti-Exonuclease 3'-5' Domain-Containing Protein 2 antibody
Anti-3'-5' Exoribonuclease Exd2 antibody
Anti-Exonuclease 3'-5' Domain-Like-Containing Protein 2 antibody
Anti-EXD2 antibody
Anti-C14orf114 antibody
Anti-EXDL2 antibody

Information sourced from Uniprot.org

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