• Western blot of HeLa cell lysate showing specific immunolabeling of the ~85 kDa EWS protein.
  • Immunofluorescence of HeLa cells showing clear localized labeling of the DNA in the nucleus with Anti-EWS (STJA0003830, 1:1000, green) while Anti-Vimentin (STJA0003823, 1:5000, red) labels the cytoplasmic intermediate filament, and Hoechst DNA stain (blue).

Anti-EWSR1 antibody (Full Length) [5H7] (STJA0003830)

SKU:
STJA0003830-100

£442.50
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Host: Mouse
Applications: WB/IHC/ICC
Reactivity: Canine/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-EWS (Full Length) is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications.
Clonality: Monoclonal
Clone ID: 5H7
Conjugation: Unconjugated
Isotype: IgG2b
Formulation: 100 ul in PBS + 50% Glycerol and 5 mM Sodium Azide
Purification: This antibody was protein g purified culture from supernatant.
Dilution Range: WB 1:1000
IHC 1:1000
ICC 1:1000
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EWSR1
Gene ID: 2130
Uniprot ID: EWS_HUMAN
Immunogen Region: Full Length
Immunogen: full length recombinant human EWS expressed in and purified from E. coli. of human species
Tissue Specificity Ubiquitous.
Post Translational Modifications Phosphorylated.calmodulin-binding inhibits phosphorylation of Ser-266. Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8.
Function Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Protein Name Rna-Binding Protein Ews
Ews Oncogene
Ewing Sarcoma Breakpoint Region 1 Protein
Cellular Localisation Nucleus
Cytoplasm
Cell Membrane
Relocates From Cytoplasm To Ribosomes Upon Ptk2b/Fak2 Activation
Alternative Antibody Names Anti-Rna-Binding Protein Ews antibody
Anti-Ews Oncogene antibody
Anti-Ewing Sarcoma Breakpoint Region 1 Protein antibody
Anti-EWSR1 antibody
Anti-EWS antibody

Information sourced from Uniprot.org

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