| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EWSR1 (1-300) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EWSR1 |
| Gene ID: |
2130 |
| Uniprot ID: |
EWS_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human EWSR1 (NP_001156757.1). |
| Immunogen Sequence: |
MASTDYSTYSQAAAQQGYSA YTAQPTQGYAQTTQAYGQQS YGTYGQPTDVSYTQAQTTAT YGQTAYATSYGQPPTGYTTP TAPQAYSQPVQGYGTGAYDT TTATVTTTQASYAAQSAYGT QPAYPAYGQQPAATAPTRPQ DGNKPTETSQPQSSTGGYNQ PSLGYGQSNYSYPQVPGSYP MQPVTAPPSYPPTSYSSTQP TSYDQSSYSQQNTYGQPSSY GQQSSYGQQSSYGQQPPTS |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated.calmodulin-binding inhibits phosphorylation of Ser-266. Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8. |
| Function | Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Protein Name | Rna-Binding Protein EwsEws OncogeneEwing Sarcoma Breakpoint Region 1 Protein |
| Cellular Localisation | NucleusCytoplasmCell MembraneRelocates From Cytoplasm To Ribosomes Upon Ptk2b/Fak2 Activation |
| Alternative Antibody Names | Anti-Rna-Binding Protein Ews antibodyAnti-Ews Oncogene antibodyAnti-Ewing Sarcoma Breakpoint Region 1 Protein antibodyAnti-EWSR1 antibodyAnti-EWS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
