| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-EVI1/AML1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
MECOM |
| Gene ID: |
2122 |
| Uniprot ID: |
MECOM_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_001098547.3; NP_005232.2; NP_004982.2; NP_001157471.1; NP_001157472.1 |
| Specificity: |
This antibody is expected to recognize all reported isoforms (NP_001098547.3; NP_005232.2; NP_004982.2; NP_001157471.1; NP_001157472.1). Reported variants represent identical protein: NP_001098548.2, NP_005232.2 |
| Immunogen Sequence: |
DKESLHSTSH |
| Function | Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Isoform 7: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. |
| Protein Name | Histone-Lysine N-Methyltransferase MecomEcotropic Virus Integration Site 1 Protein HomologEvi-1Mds1 And Evi1 Complex Locus ProteinMyelodysplasia Syndrome 1 ProteinMyelodysplasia Syndrome-Associated Protein 1 |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-8943724 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasm |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Mecom antibodyAnti-Ecotropic Virus Integration Site 1 Protein Homolog antibodyAnti-Evi-1 antibodyAnti-Mds1 And Evi1 Complex Locus Protein antibodyAnti-Myelodysplasia Syndrome 1 Protein antibodyAnti-Myelodysplasia Syndrome-Associated Protein 1 antibodyAnti-MECOM antibodyAnti-EVI1 antibodyAnti-MDS1 antibodyAnti-PRDM3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
