| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ETS2 |
| Gene ID: | 2114 |
| Uniprot ID: | ETS2_HUMAN |
| Immunogen Region: | 76-469 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 76-170 of human ETS2 (NP_005230.1). |
| Immunogen Sequence: | KAVMSQALKATFSGFKKEQR RLGIPKNPWLWSEQQVCQWL LWATNEFSLVNVNLQRFGMN GQMLCNLGKERFLELAPDFV GDILWEHLEQMIKEN |
| Post Translational Modifications | Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation. |
| Function | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. |
| Protein Name | Protein C-Ets-2 |
| Database Links | Reactome: R-HSA-2559585 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein C-Ets-2 antibodyAnti-ETS2 antibody |
Information sourced from Uniprot.org