| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ESRRG (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000. WB: Approx. 50kDa band observed in Human Brain (Cerebellum) and Breast lysates (calculated MW of 51.3kDa according to NP_NP_001429.2). In transfected HEK293 transiently expressing ESRRG a |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ESRRG |
| Gene ID: | 2104 |
| Uniprot ID: | ERR3_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_001429.2; NP_996317.1; NP_996318.1 |
| Specificity: | This antibody is expected to recognise the reported isoform NP_001429.2. |
| Immunogen Sequence: | CRMSNKDRHIDS |
| Post Translational Modifications | Acetylated by PCAF/KAT2 (in vitro). Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity. Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity. |
| Function | Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle. |
| Protein Name | Estrogen-Related Receptor Gamma Err Gamma-2 Estrogen Receptor-Related Protein 3 Nuclear Receptor Subfamily 3 Group B Member 3 |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Estrogen-Related Receptor Gamma antibody Anti-Err Gamma-2 antibody Anti-Estrogen Receptor-Related Protein 3 antibody Anti-Nuclear Receptor Subfamily 3 Group B Member 3 antibody Anti-ESRRG antibody Anti-ERR3 antibody Anti-ERRG2 antibody Anti-KIAA0832 antibody Anti-NR3B3 antibody |
Information sourced from Uniprot.org