| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S1MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ESRRA |
| Gene ID: | 2101 |
| Uniprot ID: | ERR1_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ESRRA (P11474). |
| Immunogen Sequence: | MSSQVVGIEPLYIKAEPASP DSPKGSSETETEPPVALAPG PAPTRCLPGHKEEEDGEGAG PGEQGGGKLVLSSLPKRLCL VCGDVASGYHYGVASCEACK |
| Post Translational Modifications | Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding. Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity.deacetylation involves SIRT1 and HDAC8 and increases DNA-binding. |
| Function | Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. |
| Protein Name | Steroid Hormone Receptor Err1 Estrogen Receptor-Like 1 Estrogen-Related Receptor Alpha Err-Alpha Nuclear Receptor Subfamily 3 Group B Member 1 |
| Database Links | Reactome: R-HSA-1989781 Reactome: R-HSA-2151201 Reactome: R-HSA-383280 Reactome: R-HSA-8939902 |
| Cellular Localisation | Nucleus Cytoplasm Co-Localizes To The Cytoplasm Only In Presence Of Mapk15 |
| Alternative Antibody Names | Anti-Steroid Hormone Receptor Err1 antibody Anti-Estrogen Receptor-Like 1 antibody Anti-Estrogen-Related Receptor Alpha antibody Anti-Err-Alpha antibody Anti-Nuclear Receptor Subfamily 3 Group B Member 1 antibody Anti-ESRRA antibody Anti-ERR1 antibody Anti-ESRL1 antibody Anti-NR3B1 antibody |
Information sourced from Uniprot.org