| Host: | Mouse |
| Applications: | IHC/IF/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Estrogen receptor beta (400-530 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality : | Monoclonal |
| Conjugation: | Unconjugated |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-300WB 1:500-2000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ESR2 |
| Gene ID: | 2100 |
| Uniprot ID: | ESR2_HUMAN |
| Immunogen Region: | 400-530 aa |
| Specificity: | This antibody detects endogenous levels of human Estrogen Receptor Beta |
| Immunogen: | Synthesized peptide derived from the human Estrogen Receptor Beta at the amino acid range 400-530 |
| Post Translational Modifications | Phosphorylation at Ser-87 and Ser-105 recruits NCOA1. |
| Function | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 2: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. |
| Protein Name | Estrogen Receptor BetaEr-BetaNuclear Receptor Subfamily 3 Group A Member 2 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-383280Reactome: R-HSA-6811558Reactome: R-HSA-8939211Reactome: R-HSA-9009391 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Estrogen Receptor Beta antibodyAnti-Er-Beta antibodyAnti-Nuclear Receptor Subfamily 3 Group A Member 2 antibodyAnti-ESR2 antibodyAnti-ESTRB antibodyAnti-NR3A2 antibody |
Information sourced from Uniprot.org
