| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ERN2/IRE1b (Internal) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Preliminary experiments gave an approx 37kDa band in Human Duodenum, Pancreas and Placenta lysates after 0.3µg/ml antibody staining. Please note that currently we cannot find an explana |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ERN2 |
| Gene ID: | 10595 |
| Uniprot ID: | ERN2_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_150296.3 |
| Immunogen Sequence: | QKRLQSPSKQAQPLD |
| Function | Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. |
| Protein Name | Serine/Threonine-Protein Kinase/Endoribonuclease Ire2Endoplasmic Reticulum-To-Nucleus Signaling 2Inositol-Requiring Protein 2Hire2pIre1-BetaIre1b Includes - Serine/Threonine-Protein Kinase - Endoribonuclease |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase/Endoribonuclease Ire2 antibodyAnti-Endoplasmic Reticulum-To-Nucleus Signaling 2 antibodyAnti-Inositol-Requiring Protein 2 antibodyAnti-Hire2p antibodyAnti-Ire1-Beta antibodyAnti-Ire1b Includes - Serine/Threonine-Protein Kinase - Endoribonuclease antibodyAnti-ERN2 antibodyAnti-IRE2 antibody |
Information sourced from Uniprot.org
