| Post Translational Modifications | N-glycosylated. |
| Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. |
| Protein Name | Endoplasmic Reticulum Aminopeptidase 1Arts-1Adipocyte-Derived Leucine AminopeptidaseA-LapAminopeptidase PilsPuromycin-Insensitive Leucyl-Specific AminopeptidasePils-ApType 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator |
| Database Links | Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Endoplasmic Reticulum Aminopeptidase 1 antibodyAnti-Arts-1 antibodyAnti-Adipocyte-Derived Leucine Aminopeptidase antibodyAnti-A-Lap antibodyAnti-Aminopeptidase Pils antibodyAnti-Puromycin-Insensitive Leucyl-Specific Aminopeptidase antibodyAnti-Pils-Ap antibodyAnti-Type 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator antibodyAnti-ERAP1 antibodyAnti-APPILS antibodyAnti-ARTS1 antibodyAnti-KIAA0525 antibodyAnti-UNQ584 antibodyAnti-PRO1154 antibody |
Information sourced from Uniprot.org
