Anti-EPOR nanobody [SAA0954] (STJN000165)

Anti-EPOR nanobody [SAA0954] (STJN000165)

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STJN000165
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Short Description :Alpaca monoclonal nanobody anti-Erythropoietin Receptor is suitable for use in ELISA research applications.
Applications:ELISA
Host:Alpaca
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SAA0954
Isotype:VHH-8His-Cys-tag
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:Purified by Nickel column.
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol:EPOR
Gene ID:2057
Uniprot ID:EPOR_HUMAN
Post Translational Modifications On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-454 is required for PTPN6 interaction, Tyr-426 for PTPN11. Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site. Ubiquitinated by the ECS(SOCS2) complex following ligand-binding and phosphorylation by JAK2, leading to its degradation by the proteasome. Regulation by the ECS(SOCS2) complex acts as a negative feedback loop of erythropoietin-mediated signaling pathway. Ubiquitination at Lys-281 mediates receptor internalization, whereas ubiquitination at Lys-453 promotes trafficking of activated receptors to the lysosomes for degradation. Ubiquitinated by NOSIP.appears to be either multi-monoubiquitinated or polyubiquitinated. Ubiquitination mediates proliferation and survival of EPO-dependent cells.
Function Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T: Acts as a dominant-negative receptor of EPOR-mediated signaling.
Protein Name Erythropoietin Receptor
Epo-R
Database Links Reactome: R-HSA-9006335
Reactome: R-HSA-9027276
Reactome: R-HSA-9027277
Reactome: R-HSA-9027283
Reactome: R-HSA-9027284
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform Epor-S: Secreted
Secreted And Located To The Cell Surface
Alternative Nanobody Names Anti-Erythropoietin Receptor nanobody
Anti-Epo-R nanobody
Anti-EPOR nanobody

Information sourced from Uniprot.org

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