| Post Translational Modifications | The N-terminus is blocked. The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (Probable). |
| Function | Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid. Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates. |
| Protein Name | Bifunctional Epoxide Hydrolase 2 Includes - Cytosolic Epoxide Hydrolase 2CehEpoxide HydrataseSoluble Epoxide HydrolaseSeh - Lipid-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-2142670Reactome: R-HSA-9018682Reactome: R-HSA-9033241 |
| Cellular Localisation | CytoplasmPeroxisome |
| Alternative Antibody Names | Anti-Bifunctional Epoxide Hydrolase 2 Includes - Cytosolic Epoxide Hydrolase 2 antibodyAnti-Ceh antibodyAnti-Epoxide Hydratase antibodyAnti-Soluble Epoxide Hydrolase antibodyAnti-Seh - Lipid-Phosphate Phosphatase antibodyAnti-EPHX2 antibody |
Information sourced from Uniprot.org
