| Post Translational Modifications | Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions. Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex. O-glycosylated.contains N-acetylglucosamine side chains in the C-terminal domain. |
| Function | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. |
| Protein Name | Protein 4.1P4.14.1rBand 4.1Epb4.1Erythrocyte Membrane Protein Band 4.1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexNucleus |
| Alternative Antibody Names | Anti-Protein 4.1 antibodyAnti-P4.1 antibodyAnti-4.1r antibodyAnti-Band 4.1 antibodyAnti-Epb4.1 antibodyAnti-Erythrocyte Membrane Protein Band 4.1 antibodyAnti-EPB41 antibodyAnti-E41P antibody |
Information sourced from Uniprot.org
