| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (281-330 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ENPP3 |
| Gene ID: | 5169 |
| Uniprot ID: | ENPP3_HUMAN |
| Immunogen Region: | 281-330 aa |
| Specificity: | CD203c Polyclonal Antibody detects endogenous levels of CD203c protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human ENPP3 at the amino acid range 281-330 |
| Post Translational Modifications | N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal. |
| Function | Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro. |
| Protein Name | Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 E-Npp 3 Npp3 Alkaline Phosphodiesterase I Dinucleoside Polyphosphatase Nucleotide Diphosphatase Nucleotide Pyrophosphatase Nppase Phosphodiesterase I Beta Pd-Ibeta Phosphodiesterase I/Nucleotide Pyrophosphatase 3 Cd Antigen Cd203c |
| Database Links | Reactome: R-HSA-199220 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein Apical Cell Membrane Secreted Detected At The Cell Surface Of Basophils Detected At The Apical Plasma Membrane Of Bile Duct Cells Located To The Apical Surface In Intestinal And Kidney Epithelial Cells Secreted In Serum And In Lumen Of Epithelial Cells |
| Alternative Antibody Names | Anti-Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 antibody Anti-E-Npp 3 antibody Anti-Npp3 antibody Anti-Alkaline Phosphodiesterase I antibody Anti-Dinucleoside Polyphosphatase antibody Anti-Nucleotide Diphosphatase antibody Anti-Nucleotide Pyrophosphatase antibody Anti-Nppase antibody Anti-Phosphodiesterase I Beta antibody Anti-Pd-Ibeta antibody Anti-Phosphodiesterase I/Nucleotide Pyrophosphatase 3 antibody Anti-Cd Antigen Cd203c antibody Anti-ENPP3 antibody Anti-PDNP3 antibody |
Information sourced from Uniprot.org