| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S3MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ENO1 |
| Gene ID: | 2023 |
| Uniprot ID: | ENOA_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ENO1 (P06733). |
| Immunogen Sequence: | MSILKIHAREIFDSRGNPTV EVDLFTSKGLFRAAVPSGAS TGIYEALELRDNDKTRYMGK GVSKAVEHINKTIAPALVSK KLNVTEQEKIDKLMIEMDGT |
| Tissue Specificity | The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. |
| Post Translational Modifications | ISGylated. Lysine 2-hydroxyisobutyrylation (Khib) by p300/EP300 activates the phosphopyruvate hydratase activity. |
| Function | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Isoform MBP-1: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. |
| Protein Name | Alpha-Enolase 2-Phospho-D-Glycerate Hydro-Lyase C-Myc Promoter-Binding Protein Enolase 1 Mbp-1 Mpb-1 Non-Neural Enolase Nne Phosphopyruvate Hydratase Plasminogen-Binding Protein |
| Database Links | Reactome: R-HSA-70171 Reactome: R-HSA-70263 Reactome: R-HSA-9636667 |
| Cellular Localisation | Cytoplasm Cell Membrane Myofibril Sarcomere M Line Can Translocate To The Plasma Membrane In Either The Homodimeric (Alpha/Alpha) Or Heterodimeric (Alpha/Gamma) Form Eno1 Is Localized To The M Line Isoform Mbp-1: Nucleus |
| Alternative Antibody Names | Anti-Alpha-Enolase antibody Anti-2-Phospho-D-Glycerate Hydro-Lyase antibody Anti-C-Myc Promoter-Binding Protein antibody Anti-Enolase 1 antibody Anti-Mbp-1 antibody Anti-Mpb-1 antibody Anti-Non-Neural Enolase antibody Anti-Nne antibody Anti-Phosphopyruvate Hydratase antibody Anti-Plasminogen-Binding Protein antibody Anti-ENO1 antibody Anti-ENO1L1 antibody Anti-MBPB1 antibody Anti-MPB1 antibody |
Information sourced from Uniprot.org