| Tissue Specificity | Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum. |
| Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid. |
| Protein Name | Very Long Chain Fatty Acid Elongase 53-Keto Acyl-Coa Synthase Elovl5Elovl Fatty Acid Elongase 5Elovl Fa Elongase 5Elongation Of Very Long Chain Fatty Acids Protein 5Fatty Acid Elongase 1Helo1Very Long Chain 3-Ketoacyl-Coa Synthase 5Very Long Chain 3-Oxoacyl-Coa Synthase 5 |
| Database Links | Reactome: R-HSA-2046105Reactome: R-HSA-2046106Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell ProjectionDendriteIn Purkinje CellsThe Protein Localizes To The Soma And Proximal Portion Of The Dendritic Tree |
| Alternative Antibody Names | Anti-Very Long Chain Fatty Acid Elongase 5 antibodyAnti-3-Keto Acyl-Coa Synthase Elovl5 antibodyAnti-Elovl Fatty Acid Elongase 5 antibodyAnti-Elovl Fa Elongase 5 antibodyAnti-Elongation Of Very Long Chain Fatty Acids Protein 5 antibodyAnti-Fatty Acid Elongase 1 antibodyAnti-Helo1 antibodyAnti-Very Long Chain 3-Ketoacyl-Coa Synthase 5 antibodyAnti-Very Long Chain 3-Oxoacyl-Coa Synthase 5 antibodyAnti-ELOVL5 antibodyAnti-ELOVL2 antibodyAnti-PRO0530 antibody |
Information sourced from Uniprot.org
