| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
Edf1 |
| Gene ID: |
59022 |
| Uniprot ID: |
EDF1_MOUSE |
| Immunogen Region: |
1-148 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of mouse Edf1 (NP_067494.1). |
| Immunogen Sequence: |
MAESDWDTVTVLRKKGPTAA QAKSKQAILAAQRRGEDVET SKKWAAGQNKQHSITKNTAK LDRETEELHHDRVTLEVGKV IQRGRQSKGLTQKDLATKIN EKPQVIADYESGRAIPNNQV LGKIERAIGLKLRGKDIGKP IEKGPKAK |
| Tissue Specificity | Expressed in brain, liver, kidney and heart (at protein level). Also expressed in testis. |
| Post Translational Modifications | Phosphorylated. |
| Function | Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. |
| Protein Name | Endothelial Differentiation-Related Factor 1Edf-1Multiprotein-Bridging Factor 1Mbf1 |
| Cellular Localisation | CytoplasmNucleusAlso Nuclear Upon Binding To Nr5a1 And Treatment Of Cells With Tpa Or Forskolin |
| Alternative Antibody Names | Anti-Endothelial Differentiation-Related Factor 1 antibodyAnti-Edf-1 antibodyAnti-Multiprotein-Bridging Factor 1 antibodyAnti-Mbf1 antibodyAnti-Edf1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunohistochemistry analysis of EDF1 in paraffin-embedded mouse lung using [KO Validated] EDF1 Rabbit polyclonal antibody (STJ23470) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/99544/384668/STJ23470_1__14722.1713153436.jpg?c=1 "Immunohistochemistry analysis of EDF1 in paraffin-embedded mouse lung using [KO Validated] EDF1 Rabbit polyclonal antibody (STJ23470) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.")
