| Short Description : | Rabbit polyclonal EDEM2 (399-578) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EDEM2 |
| Gene ID: | 55741 |
| Uniprot ID: | EDEM2_HUMAN |
| Immunogen Region: | 399-578 |
| Immunogen Sequence: | SIEKISKVECGFATIKDLRD HKLDNRMESFFLAETVKYLY LLFDPTNFIHNNGSTFDAVI TPYGECILGAGGYIFNTEAH PIDPAALHCCQRLKEEQWEV EDLMREFYSLKRSRSKFQKN TVSSGPWEPPARPGTLFSPE NHDQARERKPAKQKVPLLSC PSQPFTSKLALLGQVFLDSS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 399-578 of human EDEM2 (NP_060687.2). |
| Tissue Specificity | Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle. |
| Post Translational Modifications | N-glycosylated. |
| Function | Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins. |
| Protein Name | Er Degradation-Enhancing Alpha-Mannosidase-Like Protein 2 |
| Database Links | Reactome: R-HSA-901032Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Er Degradation-Enhancing Alpha-Mannosidase-Like Protein 2 antibodyAnti-EDEM2 antibodyAnti-C20orf31 antibodyAnti-C20orf49 antibodyAnti-UNQ573 antibodyAnti-PRO1135 antibody |
Information sourced from Uniprot.org
