| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EDEM2 |
| Gene ID: | 55741 |
| Uniprot ID: | EDEM2_HUMAN |
| Immunogen Region: | 399-578 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 399-578 of human EDEM2 (NP_060687.2). |
| Immunogen Sequence: | SIEKISKVECGFATIKDLRD HKLDNRMESFFLAETVKYLY LLFDPTNFIHNNGSTFDAVI TPYGECILGAGGYIFNTEAH PIDPAALHCCQRLKEEQWEV EDLMREFYSLKRSRSKFQKN TVSSGPWEPPARPGTLFSPE NHDQARERKPAKQKVPLLSC PSQPFTSKLALLGQVFLDSS |
| Tissue Specificity | Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle. |
| Post Translational Modifications | N-glycosylated. |
| Function | Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins. |
| Protein Name | Er Degradation-Enhancing Alpha-Mannosidase-Like Protein 2 |
| Database Links | Reactome: R-HSA-901032Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Er Degradation-Enhancing Alpha-Mannosidase-Like Protein 2 antibodyAnti-EDEM2 antibodyAnti-C20orf31 antibodyAnti-C20orf49 antibodyAnti-UNQ573 antibodyAnti-PRO1135 antibody |
Information sourced from Uniprot.org