| Function | Isomerase that catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers a catalytic step in the postlanosterol biosynthesis of cholesterol. Component of the microsomal antiestrogen binding site (AEBS), a multiproteic complex at the ER membrane that consists of an association between EBP and 7-dehydrocholesterol reductase/DHCR7. This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT). The precise role of each component of this complex has not been described yet. |
| Protein Name | 3-Beta-Hydroxysteroid-Delta(8 -Delta(7-IsomeraseCholestenol Delta-IsomeraseCholesterol-5 -6-Epoxide Hydrolase Subunit EbpDelta(8-Delta(7 Sterol IsomeraseD8-D7 Sterol IsomeraseEmopamil-Binding Protein |
| Database Links | Reactome: R-HSA-6807047Reactome: R-HSA-6807062 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinNucleus EnvelopeCytoplasmic VesicleDuring InterphaseDetected On The Endoplasmic Reticulum And The Nuclear EnvelopeDuring MitosisDetected On Cytoplasmic Vesicles |
| Alternative Antibody Names | Anti-3-Beta-Hydroxysteroid-Delta(8 -Delta(7-Isomerase antibodyAnti-Cholestenol Delta-Isomerase antibodyAnti-Cholesterol-5 -6-Epoxide Hydrolase Subunit Ebp antibodyAnti-Delta(8-Delta(7 Sterol Isomerase antibodyAnti-D8-D7 Sterol Isomerase antibodyAnti-Emopamil-Binding Protein antibodyAnti-EBP antibody |
Information sourced from Uniprot.org
