| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | E2F4 |
| Gene ID: | 1874 |
| Uniprot ID: | E2F4_HUMAN |
| Immunogen Region: | 89-198 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 89-198 of human E2F4 (NP_001941.2). |
| Immunogen Sequence: | NTREIADKLIELKAEIEELQ QREQELDQHKVWVQQSIRNV TEDVQNSCLAYVTHEDICRC FAGDTLLAIRAPSGTSLEVP IPEGLNGQKKYQIHLKSVSG PIEVLLVNKE |
| Tissue Specificity | Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Differentially phosphorylated in vivo. |
| Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. |
| Protein Name | Transcription Factor E2f4 E2f-4 |
| Database Links | Reactome: R-HSA-1362277 Reactome: R-HSA-1362300 Reactome: R-HSA-1538133 Reactome: R-HSA-2173796 Reactome: R-HSA-6804114 Reactome: R-HSA-69202 Reactome: R-HSA-69205 Reactome: R-HSA-69231 Reactome: R-HSA-69656 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor E2f4 antibody Anti-E2f-4 antibody Anti-E2F4 antibody |
Information sourced from Uniprot.org