Anti-DVL1 antibody (STJ192994)

SKU:
STJ192994

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Segment polarity protein dishevelled homolog DVL-1 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DVL1
Gene ID: 1855
Uniprot ID: DVL1_HUMAN
Specificity: DVL1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Function Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Protein Name Segment Polarity Protein Dishevelled Homolog Dvl-1
Dishevelled-1
Dsh Homolog 1
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-201688
Reactome: R-HSA-4086400
Reactome: R-HSA-4641258
Reactome: R-HSA-4641262
Reactome: R-HSA-5368598
Reactome: R-HSA-5663220
Reactome: R-HSA-9673324
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytosol
Cytoplasmic Vesicle
Localizes At The Cell Membrane Upon Interaction With Frizzled Family Members
Alternative Antibody Names Anti-Segment Polarity Protein Dishevelled Homolog Dvl-1 antibody
Anti-Dishevelled-1 antibody
Anti-Dsh Homolog 1 antibody
Anti-DVL1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance