| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Dual specificity protein phosphatase 4 (81-130) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DUSP4 |
| Gene ID: | 1846 |
| Uniprot ID: | DUS4_HUMAN |
| Immunogen Region: | 81-130 |
| Specificity: | MKP-2 Polyclonal Antibody detects endogenous levels of MKP-2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human DUSP4. AA range:81-130 |
| Post Translational Modifications | Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein. |
| Function | Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. |
| Protein Name | Dual Specificity Protein Phosphatase 4Dual Specificity Protein Phosphatase Hvh2Mitogen-Activated Protein Kinase Phosphatase 2Map Kinase Phosphatase 2Mkp-2 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 4 antibodyAnti-Dual Specificity Protein Phosphatase Hvh2 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 2 antibodyAnti-Map Kinase Phosphatase 2 antibodyAnti-Mkp-2 antibodyAnti-DUSP4 antibodyAnti-MKP2 antibodyAnti-VH2 antibody |
Information sourced from Uniprot.org