| Post Translational Modifications | Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity. (Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein.this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis. |
| Function | Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. |
| Protein Name | Dual Specificity Protein Phosphatase 16Mitogen-Activated Protein Kinase Phosphatase 7Map Kinase Phosphatase 7Mkp-7 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-5675221Reactome: R-HSA-9636569Reactome: R-HSA-9652817 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic VesicleAfter Dissociation Upon Agtr StimulationRe-Associates With Arrb2 On Endocytic Vesicles |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 16 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 7 antibodyAnti-Map Kinase Phosphatase 7 antibodyAnti-Mkp-7 antibodyAnti-DUSP16 antibodyAnti-KIAA1700 antibodyAnti-MKP7 antibody |
Information sourced from Uniprot.org
