| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DTNB |
| Gene ID: | 1838 |
| Uniprot ID: | DTNB_HUMAN |
| Immunogen Region: | 381-560 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 381-560 of human DTNB (NP_899205.1). |
| Immunogen Sequence: | RLAAEAGNVTRPPTDLSFNF DANKQQRQLIAELENKNREI LQEIQRLRLEHEQASQPTPE KAQQNPTLLAELRLLRQRKD ELEQRMSALQESRRELMVQL EELMKLLKAQATGSPHTSPT HGGGRPMPMPVRSTSAGSTP THCPQDSLSGVGGDVQEAFA QAEEGAEEEEEKMQNGKDRG |
| Tissue Specificity | Highly expressed in brain, kidney and pancreas. |
| Post Translational Modifications | Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A. |
| Function | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses. |
| Protein Name | Dystrobrevin BetaDtn-BBeta-Dystrobrevin |
| Cellular Localisation | CytoplasmPostsynaptic DensityCell ProjectionDendriteBasal Cell MembranePostsynapseNucleusLocalized At Inhibitory Synapses On The Dendrites Of Cerebellar Purkinje Cells |
| Alternative Antibody Names | Anti-Dystrobrevin Beta antibodyAnti-Dtn-B antibodyAnti-Beta-Dystrobrevin antibodyAnti-DTNB antibody |
Information sourced from Uniprot.org