• Western blot analysis of extracts of mouse brain, using DTNB antibody (STJ114732) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-DTNB antibody (381-560) (STJ114732)

SKU:
STJ114732

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DTNB (381-560) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DTNB
Gene ID: 1838
Uniprot ID: DTNB_HUMAN
Immunogen Region: 381-560
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 381-560 of human DTNB (NP_899205.1).
Immunogen Sequence: RLAAEAGNVTRPPTDLSFNF DANKQQRQLIAELENKNREI LQEIQRLRLEHEQASQPTPE KAQQNPTLLAELRLLRQRKD ELEQRMSALQESRRELMVQL EELMKLLKAQATGSPHTSPT HGGGRPMPMPVRSTSAGSTP THCPQDSLSGVGGDVQEAFA QAEEGAEEEEEKMQNGKDRG
Tissue Specificity Highly expressed in brain, kidney and pancreas.
Post Translational Modifications Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A.
Function Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses.
Protein Name Dystrobrevin Beta
Dtn-B
Beta-Dystrobrevin
Cellular Localisation Cytoplasm
Postsynaptic Density
Cell Projection
Dendrite
Basal Cell Membrane
Postsynapse
Nucleus
Localized At Inhibitory Synapses On The Dendrites Of Cerebellar Purkinje Cells
Alternative Antibody Names Anti-Dystrobrevin Beta antibody
Anti-Dtn-B antibody
Anti-Beta-Dystrobrevin antibody
Anti-DTNB antibody

Information sourced from Uniprot.org

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