| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Desmoplakin (1546-1596 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DSP |
| Gene ID: |
1832 |
| Uniprot ID: |
DESP_HUMAN |
| Immunogen Region: |
1546-1596 aa |
| Specificity: |
This antibody detects endogenous levels of DESP at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human DESP at the amino acid range 1546-1596 |
| Function | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance. |
| Protein Name | DesmoplakinDp250/210 Kda Paraneoplastic Pemphigus Antigen |
| Database Links | Reactome: R-HSA-351906Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9696264Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell JunctionDesmosomeCell MembraneLocalizes At The Intercalated Disk In Cardiomyocytes |
| Alternative Antibody Names | Anti-Desmoplakin antibodyAnti-Dp antibodyAnti-250/210 Kda Paraneoplastic Pemphigus Antigen antibodyAnti-DSP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
