| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DSG2 |
| Gene ID: | 1829 |
| Uniprot ID: | DSG2_HUMAN |
| Immunogen Region: | 635-935 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 635-935 of human DSG2 (NP_001934.2). |
| Immunogen Sequence: | CHCGKGAKGFTPIPGTIEML HPWNNEGAPPEDKVVPSFLP VDQGGSLVGRNGVGGMAKEA TMKGSSSASIVKGQHEMSEM DGRWEEHRSLLSGRATQFTG ATGAIMTTETTKTARATGAS RDMAGAQAAAVALNEEFLRN YFTDKAASYTEEDENHTAKD CLLVYSQEETESLNASIGCC SFIEGELDDRFLDDLGLKFK TLAEVCLGQKIDINKEIEQR QKPATETSMNTASHSLCEQ |
| Tissue Specificity | All of the tissues tested and carcinomas. |
| Post Translational Modifications | Palmitoylated by ZDHHC5 at the plasma membrane. |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
| Protein Name | Desmoglein-2Cadherin Family Member 5Hdgc |
| Database Links | Reactome: R-HSA-351906Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9013423 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosome |
| Alternative Antibody Names | Anti-Desmoglein-2 antibodyAnti-Cadherin Family Member 5 antibodyAnti-Hdgc antibodyAnti-DSG2 antibodyAnti-CDHF5 antibody |
Information sourced from Uniprot.org