| Host: | Goat |
| Applications: | Pep-ELISA/IF/FC |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-DSCR2/PSMG1 (C-Term) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.IF: Strong expression of the protein seen in the cytoplasm and Golgi apparatus of A431 and U2OS cells. Recommended concentration: 10µg/ml. FC:Flow cytometric analysis of Jurkat cells. Re |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PSMG1 |
| Gene ID: | 8624 |
| Uniprot ID: | PSMG1_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_003711.1; NP_982257.1; NP_001248753.1; NP_001307724.1 |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_003711.1; NP_982257.1;NP_001248753.1; NP_001307724.1) |
| Immunogen Sequence: | KLMTTNEIQSNIYT |
| Post Translational Modifications | Degraded by the proteasome upon completion of 20S proteasome maturation. |
| Function | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. |
| Protein Name | Proteasome Assembly Chaperone 1Pac-1Chromosome 21 Leucine-Rich ProteinC21-LrpDown Syndrome Critical Region Protein 2Proteasome Chaperone Homolog 1Pba1 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Proteasome Assembly Chaperone 1 antibodyAnti-Pac-1 antibodyAnti-Chromosome 21 Leucine-Rich Protein antibodyAnti-C21-Lrp antibodyAnti-Down Syndrome Critical Region Protein 2 antibodyAnti-Proteasome Chaperone Homolog 1 antibodyAnti-Pba1 antibodyAnti-PSMG1 antibodyAnti-C21LRP antibodyAnti-DSCR2 antibodyAnti-PAC1 antibody |
Information sourced from Uniprot.org