| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DSC2 |
| Gene ID: | 1824 |
| Uniprot ID: | DSC2_HUMAN |
| Immunogen Region: | 520-690 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-690 of human DSC2 (NP_077740.1). |
| Immunogen Sequence: | IDENTGSIKVFRSLDREAET IKNGIYNITVLASDQGGRTC TGTLGIILQDVNDNSPFIPK KTVIICKPTMSSAEIVAVDP DEPIHGPPFDFSLESSTSEV QRMWRLKAINDTAARLSYQN DPPFGSYVVPITVRDRLGMS SVTSLDVTLCDCITENDCTH RVDPRIGGGGV |
| Tissue Specificity | Expressed in the heart (at protein level). |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration. |
| Protein Name | Desmocollin-2Cadherin Family Member 2Desmocollin-3Desmosomal Glycoprotein IiDesmosomal Glycoprotein Iii |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosome |
| Alternative Antibody Names | Anti-Desmocollin-2 antibodyAnti-Cadherin Family Member 2 antibodyAnti-Desmocollin-3 antibodyAnti-Desmosomal Glycoprotein Ii antibodyAnti-Desmosomal Glycoprotein Iii antibodyAnti-DSC2 antibodyAnti-CDHF2 antibodyAnti-DSC3 antibody |
Information sourced from Uniprot.org