| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DSC1 |
| Gene ID: | 1823 |
| Uniprot ID: | DSC1_HUMAN |
| Immunogen Region: | 480-690 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 480-690 of human DSC1 (NP_077739.1). |
| Immunogen Sequence: | SQDGFPAGQELLGYKALDPE ISSGEGLRYQKLGDEDNWFE INQHTGDLRTLKVLDRESKF VKNNQYNISVVAVDAVGRSC TGTLVVHLDDYNDHAPQIDK EVTICQNNEDFAVLKPVDPD GPENGPPFQFFLDNSASKNW NIEEKDGKTAILRQRQNLDY NYYSVPIQIKDRHGLVATHM LTVRVCDCSTPSECRMKDKS TRDVRPNVILG |
| Tissue Specificity | Strongly expressed in epidermis, less in lymph node and tongue. |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Required for desmosome adhesion strength between the granular layers of the epidermis, as a result moderates epidermal proliferation and differentiation. Is therefore required to maintain postnatal epidermal barrier function and normal hair follicle morphology into adulthood. |
| Protein Name | Desmocollin-1Cadherin Family Member 1Desmosomal Glycoprotein 2/3Dg2/Dg3 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosome |
| Alternative Antibody Names | Anti-Desmocollin-1 antibodyAnti-Cadherin Family Member 1 antibodyAnti-Desmosomal Glycoprotein 2/3 antibodyAnti-Dg2/Dg3 antibodyAnti-DSC1 antibodyAnti-CDHF1 antibody |
Information sourced from Uniprot.org
