Anti-DPYSL2 antibody (473-572) [S4MR] (STJ11102074)

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STJ11102074
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S4MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:5000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DPYSL2
Gene ID: 1808
Uniprot ID: DPYL2_HUMAN
Immunogen Region: 473-572
Specificity: A synthetic peptide corresponding to a sequence within amino acids 473-572 of human CRMP2/DPYSL2 (Q16555).
Immunogen Sequence: PFPDFVYKRIKARSRLAELR GVPRGLYDGPVCEVSVTPKT VTPASSAKTSPAKQQAPPVR NLHQSGFSLSGAQIDDNIPR RTTQRIVAPPGGRANITSLG
Tissue Specificity Ubiquitous.
Post Translational Modifications 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration. Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
Function Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Protein Name Dihydropyrimidinase-Related Protein 2
Drp-2
Collapsin Response Mediator Protein 2
Crmp-2
N2a3
Unc-33-Like Phosphoprotein 2
Ulip-2
Database Links Reactome: R-HSA-399956
Reactome: R-HSA-437239
Cellular Localisation Cytoplasm
Cytosol
Cytoskeleton
Membrane
Tightly But Non-Covalently Associated With Membranes
Alternative Antibody Names Anti-Dihydropyrimidinase-Related Protein 2 antibody
Anti-Drp-2 antibody
Anti-Collapsin Response Mediator Protein 2 antibody
Anti-Crmp-2 antibody
Anti-N2a3 antibody
Anti-Unc-33-Like Phosphoprotein 2 antibody
Anti-Ulip-2 antibody
Anti-DPYSL2 antibody
Anti-CRMP2 antibody
Anti-ULIP2 antibody

Information sourced from Uniprot.org