| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-CRMP2 (473-572) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:5000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DPYSL2 |
| Gene ID: |
1808 |
| Uniprot ID: |
DPYL2_HUMAN |
| Immunogen Region: |
473-572 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 473-572 of human CRMP2/DPYSL2 (Q16555). |
| Immunogen Sequence: |
PFPDFVYKRIKARSRLAELR GVPRGLYDGPVCEVSVTPKT VTPASSAKTSPAKQQAPPVR NLHQSGFSLSGAQIDDNIPR RTTQRIVAPPGGRANITSLG |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration. Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. |
| Function | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. |
| Protein Name | Dihydropyrimidinase-Related Protein 2Drp-2Collapsin Response Mediator Protein 2Crmp-2N2a3Unc-33-Like Phosphoprotein 2Ulip-2 |
| Database Links | Reactome: R-HSA-399956Reactome: R-HSA-437239 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonMembraneTightly But Non-Covalently Associated With Membranes |
| Alternative Antibody Names | Anti-Dihydropyrimidinase-Related Protein 2 antibodyAnti-Drp-2 antibodyAnti-Collapsin Response Mediator Protein 2 antibodyAnti-Crmp-2 antibodyAnti-N2a3 antibodyAnti-Unc-33-Like Phosphoprotein 2 antibodyAnti-Ulip-2 antibodyAnti-DPYSL2 antibodyAnti-CRMP2 antibodyAnti-ULIP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunohistochemistry analysis of CRMP2/DPYSL2 in paraffin-embedded mouse brain using [KO Validated] CRMP2/CRMP2/DPYSL2 Rabbit polyclonal antibody (STJ116781) at dilution of 1:400 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/95755/377906/STJ116781_1__52305.1713145321.jpg?c=1 "Immunohistochemistry analysis of CRMP2/DPYSL2 in paraffin-embedded mouse brain using [KO Validated] CRMP2/CRMP2/DPYSL2 Rabbit polyclonal antibody (STJ116781) at dilution of 1:400 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
