| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DPYS |
| Gene ID: | 1807 |
| Uniprot ID: | DPYS_HUMAN |
| Immunogen Region: | 250-519 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-519 of human DPYS (NP_001376.1). |
| Immunogen Sequence: | MSKSAAKVIADARRDGKVVY GEPIAASLGTDGTHYWNKEW HHAAHHVMGPPLRPDPSTPD FLMNLLANDDLTTTGTDNCT FNTCQKALGKDDFTKIPNGV NGVEDRMSVIWEKGVHSGKM DENRFVAVTSTNAAKIFNLY PRKGRIAVGSDADIVIWDPK GTRTISAKTHHQAVNFNIFE GMVCHGVPLVTISRGKVVYE AGVFSVTAGDGKFIPRKPFA EYIYKRIKQRDRTCTPTPV |
| Tissue Specificity | Liver and kidney. |
| Post Translational Modifications | Carboxylation allows a single lysine to coordinate two zinc ions. |
| Function | Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. |
| Protein Name | DihydropyrimidinaseDhpDhpaseDihydropyrimidine AmidohydrolaseHydantoinase |
| Database Links | Reactome: R-HSA-73621 |
| Alternative Antibody Names | Anti-Dihydropyrimidinase antibodyAnti-Dhp antibodyAnti-Dhpase antibodyAnti-Dihydropyrimidine Amidohydrolase antibodyAnti-Hydantoinase antibodyAnti-DPYS antibody |
Information sourced from Uniprot.org