| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DOT1L |
| Gene ID: | 84444 |
| Uniprot ID: | DOT1L_HUMAN |
| Immunogen Region: | 1438-1537 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1438-1537 of human Dot1L/KMT4 (NP_115871.1). |
| Immunogen Sequence: | LLSGPGLAPAASSAGGAASS AQTHRSFLGPFPPGPQFALG PMSLQANLGSVAGSSVLQSL FSSVPAAAGLVHVSSAATRL TNSHAMGSFSGVAGGTVGGN |
| Function | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. |
| Protein Name | Histone-Lysine N-Methyltransferase - H3 Lysine-79 Specific Dot1-Like Protein Histone H3-K79 Methyltransferase H3-K79-Hmtase Lysine N-Methyltransferase 4 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase - H3 Lysine-79 Specific antibody Anti-Dot1-Like Protein antibody Anti-Histone H3-K79 Methyltransferase antibody Anti-H3-K79-Hmtase antibody Anti-Lysine N-Methyltransferase 4 antibody Anti-DOT1L antibody Anti-KIAA1814 antibody Anti-KMT4 antibody |
Information sourced from Uniprot.org