Anti-DOK5 antibody (237-306) (STJ115679)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DOK5 (237-306) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DOK5 |
| Gene ID | 55816 |
| Uniprot ID | DOK5_HUMAN |
| Immunogen Region | 237-306 |
| Immunogen Sequence | LLQSVKNSMLQMKMSERAAS LSTMVPLPRSAYWQHITRQH STGQLYRLQDVSSPLKLHRT ETFPAYRSEH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 237-306 of human DOK5 (NP_060901.2). |
Additional Info
| Tissue Specificity | Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF. |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
| Protein Name | Docking Protein 5Downstream Of Tyrosine Kinase 5Insulin Receptor Substrate 6Irs-6Irs6 |
| Database Links | Reactome: R-HSA-8853659 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Docking Protein 5 antibodyAnti-Downstream Of Tyrosine Kinase 5 antibodyAnti-Insulin Receptor Substrate 6 antibodyAnti-Irs-6 antibodyAnti-Irs6 antibodyAnti-DOK5 antibodyAnti-C20orf180 antibody |
Information sourced from Uniprot.org