| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DOK5 (237-306) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DOK5 |
| Gene ID: |
55816 |
| Uniprot ID: |
DOK5_HUMAN |
| Immunogen Region: |
237-306 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 237-306 of human DOK5 (NP_060901.2). |
| Immunogen Sequence: |
LLQSVKNSMLQMKMSERAAS LSTMVPLPRSAYWQHITRQH STGQLYRLQDVSSPLKLHRT ETFPAYRSEH |
| Tissue Specificity | Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF. |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
| Protein Name | Docking Protein 5Downstream Of Tyrosine Kinase 5Insulin Receptor Substrate 6Irs-6Irs6 |
| Database Links | Reactome: R-HSA-8853659 |
| Alternative Antibody Names | Anti-Docking Protein 5 antibodyAnti-Downstream Of Tyrosine Kinase 5 antibodyAnti-Insulin Receptor Substrate 6 antibodyAnti-Irs-6 antibodyAnti-Irs6 antibodyAnti-DOK5 antibodyAnti-C20orf180 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
