Western blot analysis of various lysates using DOK5 Rabbit polyclonal antibody (STJ115679) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-DOK5 antibody (237-306) (STJ115679)

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STJ115679
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DOK5
Gene ID: 55816
Uniprot ID: DOK5_HUMAN
Immunogen Region: 237-306
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 237-306 of human DOK5 (NP_060901.2).
Immunogen Sequence: LLQSVKNSMLQMKMSERAAS LSTMVPLPRSAYWQHITRQH STGQLYRLQDVSSPLKLHRT ETFPAYRSEH
Tissue Specificity Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
Post Translational Modifications Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Protein Name Docking Protein 5
Downstream Of Tyrosine Kinase 5
Insulin Receptor Substrate 6
Irs-6
Irs6
Database Links Reactome: R-HSA-8853659
Alternative Antibody Names Anti-Docking Protein 5 antibody
Anti-Downstream Of Tyrosine Kinase 5 antibody
Anti-Insulin Receptor Substrate 6 antibody
Anti-Irs-6 antibody
Anti-Irs6 antibody
Anti-DOK5 antibody
Anti-C20orf180 antibody

Information sourced from Uniprot.org

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