| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Dedicator of cytokinesis protein 3 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DOCK3 |
| Gene ID: |
1795 |
| Uniprot ID: |
DOCK3_HUMAN |
| Specificity: |
This antibody detects endogenous levels of DOCK3; MOCA at Human |
| Immunogen: |
Synthesized peptide derived from human DOCK3; MOCA |
| Function | Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors. |
| Protein Name | Dedicator Of Cytokinesis Protein 3Modifier Of Cell AdhesionPresenilin-Binding ProteinPbp |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9032759Reactome: R-HSA-983231 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 3 antibodyAnti-Modifier Of Cell Adhesion antibodyAnti-Presenilin-Binding Protein antibodyAnti-Pbp antibodyAnti-DOCK3 antibodyAnti-KIAA0299 antibodyAnti-MOCA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
