Host: | Goat |
Applications: | WB |
Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-DOCK1 (C-Term) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | WB-Recommended for use at 3-4µg/ml |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | DOCK1 |
Gene ID: | 1793 |
Uniprot ID: | DOCK1_HUMAN |
Immunogen Region: | C-Term |
Accession Number: | NP_001371.1 |
Immunogen Sequence: | TTRKQTSVDSGIVQ |
Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. |
Protein Name | Dedicator Of Cytokinesis Protein 1180 Kda Protein Downstream Of CrkDock180 |
Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-418885Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9664422Reactome: R-HSA-983231 |
Cellular Localisation | CytoplasmMembraneRecruited To Membranes Via Its Interaction With Phosphatidylinositol 345-Trisphosphate |
Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 1 antibodyAnti-180 Kda Protein Downstream Of Crk antibodyAnti-Dock180 antibodyAnti-DOCK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance